Open AccessMonoclonal and Single Domain Antibodies Targeting β-Integrin Subunits Block Sexual Transmission of HIV-1 in In Vitro and In Vivo Model Systems
Author(s) -
Janet Tai Guedon,
Kun Luo,
Hong Zhang,
Richard B. Markham
Publication year - 2015
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000609
Subject(s) - monoclonal antibody , virology , microbicide , biology , microbicides for sexually transmitted diseases , sexual transmission , antibody , in vivo , lentivirus , immunology , virus , medicine , population , human immunodeficiency virus (hiv) , viral disease , environmental health , microbiology and biotechnology , health services
Poor adherence to prevention regimens for gel-based anti-HIV-1 microbicides has been a major obstacle to more effective pre-exposure prophylaxis. Concern persists that the antiretroviral drug containing microbicides might promote development of antiretroviral resistance.