Open AccessDepot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1–Uninfected Women
Author(s) -
Brandon L. Guthrie,
Andrea Introini,
Alison C. Roxby,
Robert Y. Choi,
Rose Bosire,
Barbara Lohman-Payne,
Taha Hirbod,
Carey Farquhar,
Kristina Broliden
Publication year - 2015
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000533
Subject(s) - medroxyprogesterone acetate , hormonal contraception , lactoferrin , medicine , hormone , medroxyprogesterone , immune system , population , physiology , immunology , slpi , family planning , biology , inflammation , research methodology , environmental health , genetics
The effects of sex hormones on the immune defenses of the female genital mucosa and its susceptibility to infections are poorly understood. The injectable hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may increase the risk for HIV-1 acquisition. We assessed the local concentration in the female genital mucosa of cationic polypeptides with reported antiviral activity in relation to DMPA use.