Open AccessEffect of Pregnancy and the Postpartum Period on Adherence to Antiretroviral Therapy Among HIV-Infected Women Established on Treatment
Author(s) -
Cassidy Henegar,
Daniel Westreich,
Mhairi Maskew,
William C. Miller,
M. Alan Brookhart,
Annelies Van Rie
Publication year - 2015
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000501
Subject(s) - medicine , pregnancy , confidence interval , postpartum period , antiretroviral therapy , obstetrics , retrospective cohort study , cohort study , human immunodeficiency virus (hiv) , cohort , gynecology , viral load , immunology , genetics , biology
: Among women who become pregnant after initiating highly active antiretroviral therapy (HAART), few data describe the effect of pregnancy and postpartum on adherence. We conducted a retrospective clinical cohort study among therapy-naive women (age, 18-45 years) initiating HAART in Johannesburg, South Africa. Among 7510 women in our analysis, 896 experienced a pregnancy after starting HAART. Compared with nonpregnant periods of follow-up, there was an increased risk of nonadherence during the postpartum period (weighted risk ratio: 1.46, 95% confidence interval: 1.17 to 1.82) but not during pregnancy itself (weighted risk ratio: 0.95, 95% confidence interval: 0.78 to 1.17).