Open AccessInnate Activation of MDC and NK Cells in High-Risk HIV-1–Exposed Seronegative IV-Drug Users Who Share Needles When Compared With Low-Risk Nonsharing IV-Drug User Controls
Author(s) -
Costin Tomescu,
Kelly E. Seaton,
Peter L. Smith,
Mack Taylor,
Georgia D. Tomaras,
David Metzger,
Luis J. Montaner
Publication year - 2015
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000470
Subject(s) - innate immune system , immunology , degranulation , antibody , immune system , cd8 , medicine , receptor
Previous studies have described increased innate immune activation in HIV-1-exposed seronegative intravenous drug users (HESN-IDU), but have not addressed the independent role of injected drugs and/or repeated injections in driving immune activation.