Open AccessBrief Report
Author(s) -
Connie J. Kim,
Colin Kovacs,
TaeWook Chun,
Gabor Kandel,
B. Osborne,
Sanja Huibner,
Kamnoosh Shahabi,
Feng-Yun Yue,
Erika Benko,
Mario Ostowski,
Rupert Kaul
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000359
Subject(s) - pathogenesis , cd8 , cd4 cd8 ratio , immune system , immunology , immune dysfunction , antiretroviral therapy , medicine , human immunodeficiency virus (hiv) , viral load , gastroenterology , lymphocyte subsets
Elite controllers (ECs) maintain undetectable HIV viral loads without antiretroviral therapy (ART) but are at increased risk of serious non-AIDS conditions (SNA). We assessed the impact of ART in ECs on gut immune dysfunction and biomarkers predicting SNA (blood CD4/CD8 ratio, plasma IL-6, D-dimer levels). At baseline, ECs had elevated IL-6 and D-dimer levels and reduced CD4/CD8 ratio compared with HIV-uninfected controls, but no difference in microbial translocation or gut CD4 subsets. ART increased CD4/CD8 ratio but did not normalize IL-6 and D-dimer levels. EC SNA pathogenesis may be independent of gut immune dysfunction, and resolution may require prolonged ART.