Open AccessBrief Report
Author(s) -
Vivek Naranbhai,
Dhayendre Moodley,
Tsungai Chipato,
Lynda StranixChibanda,
Clemensia. Nakabaiito,
Moreen Kamateeka,
Philippa Musoke,
Karim Manji,
Kathleen George,
Lynda Emel,
Paul Richardson,
P. Andrew,
M E Fowler,
Helen A. Fletcher,
Helen McShane,
Hoosen Coovadia,
Adrian V. S. Hill
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000353
Subject(s) - hazard ratio , medicine , confidence interval , tuberculosis , tanzania , sex ratio , disease , immunology , population , environmental health , pathology , environmental science , environmental planning
Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte:lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).