Open AccessLow-Level Viremia Early in HIV Infection
Author(s) -
IMing Chen,
Vanessa Cummings,
Jessica M. Fogel,
Mark A. Marzinke,
William Clarke,
Matthew B. Connor,
Sam Griffith,
Susan Buchbinder,
Steven Shoptaw,
Carlos del Rı́o,
Manya Magnus,
Sharon Mannheimer,
Darrell P. Wheeler,
Kenneth H. Mayer,
Beryl A. Koblin,
Susan H. Eshleman
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000298
Subject(s) - viremia , human immunodeficiency virus (hiv) , antiretroviral drug , virology , hiv diagnosis , lentivirus , immunology , medicine , viral load , sida , drug resistance , biology , viral disease , antiretroviral therapy , microbiology and biotechnology
HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.