Open AccessAltered Innate Immune Development in HIV-Exposed Uninfected Infants
Author(s) -
Brian A. Reikie,
Rozanne C. M. Adams,
Aleksandra Leligdowicz,
Kevin Ho,
Shaleidoo,
Candice E. Ruck,
Corena de Beer,
Wolfgang Preiser,
Mark F. Cotton,
David P. Speert,
Monika Esser,
Tobias R. Kollmann
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000161
Subject(s) - immunology , immune system , cytokine , peripheral blood mononuclear cell , innate immune system , biology , medicine , biochemistry , in vitro
Early in life, HIV-exposed uninfected (HEU) infants are at an increased risk of morbidity and mortality from infectious disease compared with HIV-unexposed (UE) infants. To improve our understanding of the mechanisms underlying their increased risk, we contrasted innate immune development between HEU and UE infants in a developing world setting, where early life infectious disease risk is exceptionally high.