Open AccessTuberculosis Immune Reconstitution Inflammatory Syndrome in A5221 STRIDE
Author(s) -
Anne F Luetkemeyer,
Michelle A. Kendall,
Mulinda Nyirenda,
Xingye Wu,
Prudence Ive,
Constance A. Benson,
Janet Andersen,
Susan Swindells,
Ian Sanne,
Diane V. Havlir,
Johnstone Kumwenda
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000030
Subject(s) - immune reconstitution inflammatory syndrome , medicine , tuberculosis , iris (biosensor) , antiretroviral therapy , surgery , tb treatment , human immunodeficiency virus (hiv) , immunology , viral load , pathology , computer security , computer science , biometrics
Earlier initiation of antiretroviral therapy (ART) in HIV-tuberculosis (TB) is associated with increased immune reconstitution inflammatory syndrome (IRIS). The severity, frequency, and complications of TB IRIS were evaluated in A5221, a randomized trial of earlier ART (within 2 weeks after TB treatment initiation) vs. later ART (8-12 weeks after TB treatment) in HIV-infected patients starting TB treatment.