Open AccessAnti-HIV IgA isotypes
Author(s) -
Jennifer Watkins,
Anton M. Sholukh,
Muhammad M. Mukhtar,
Nagadenahalli B. Siddappa,
Samir K. Lakhashe,
Mi-Kyung Kim,
Ellis L. Reinherz,
Sandeep Gupta,
Donald N. Forthal,
Quentin J. Sattentau,
François Villinger,
Davide Corti,
Ruth M. Ruprecht
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328360eac6
Subject(s) - human immunodeficiency virus (hiv) , virology , immunology , immunopathology , medicine , biology
Although passive immunization with anti-HIV-1 Env IgG1 neutralizing monoclonal antibodies (nmAbs) prevented simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys, IgA nmAbs have not been tested. Here, we sought to determine whether human anti-HIV-1 dimeric (d)IgA1, dIgA2, and IgG1 differ in their ability to prevent mucosal R5 SHIV acquisition in rhesus monkeys.