Open AccessImmunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection
Author(s) -
Patrick Unemori,
Kieron Leslie,
Peter W. Hunt,
Elizabeth Sinclair,
Lorrie Epling,
Ronald T. Mitsuyasu,
Rita B. Effros,
Jeffrey Dock,
Sheila Dollard,
Steven G. Deeks,
Jeffrey N. Martin,
Toby Maurer
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283601144
Subject(s) - immunosenescence , cd8 , cd28 , sarcoma , telomere , kaposi's sarcoma , immunophenotyping , t cell , telomerase , immunology , population , senescence , immune system , biology , medicine , virology , pathology , flow cytometry , genetics , dna , human herpesvirus , environmental health , gene
Some antiretroviral treated HIV-infected patients develop Kaposi's sarcoma despite long-term suppression of HIV replication. These Kaposi's sarcoma lesions are consistent with Kaposi's sarcoma observed in the elderly uninfected population ('classical Kaposi's sarcoma'). We investigated potential mechanisms for this phenomenon, focusing on measures of immune activation and T-cell senescence.