Open AccessAge-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adults
Author(s) -
Gautam Baheti,
Jennifer R. King,
Edward P. Acosta,
Courtney V. Fletcher
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835a9a2d
Subject(s) - pharmacokinetics , dosing , population , medicine , covariate , physiology , statistics , mathematics , environmental health
There is limited pediatric information on the complex relationships among the dose of tenofovir disoproxil fumarate (TDF), plasma concentrations of tenofovir (TFV), and intracellular TFV diphosphate (TFV-DP) concentrations. Our objectives were to describe TFV-DP pharmacokinetics in children and adolescents and investigate the effect of age on TFV and TFV-DP concentrations.