Open AccessPolyclonal serum-free light chains elevation in HIV-infected patients
Author(s) -
Michele Bibas,
Patrizia Lorenzini,
Alessandro CozziLepri,
Andrea Calcagno,
Simona Di Giambenedetto,
Andrea Costantini,
Antonella Castagna,
Vinicio Manfrin,
Antonella d’Arminio Monforte,
Andrea Antinori
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328358d54b
Subject(s) - viremia , polyclonal antibodies , cohort , immunoglobulin light chain , human immunodeficiency virus (hiv) , viral load , medicine , antiretroviral therapy , immunology , viral disease , cohort study , serum concentration , multicenter aids cohort study , virology , gastroenterology , antibody
We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.