Open AccessImpact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers
Author(s) -
Costin Tomescu,
Fuh Mei Duh,
Rebecca Hoh,
Anne Viviani,
Kara Harvill,
Maureen P. Martin,
Mary Carrington,
Steven G. Deeks,
Luis J. Montaner
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835861b0
Subject(s) - biology , cytotoxic t cell , immunology , degranulation , cd8 , human leukocyte antigen , immune system , t cell , interleukin 21 , natural killer cell , natural killer t cell , virology , antigen , receptor , genetics , in vitro
Both protective T-cell genotypes and natural killer (NK) cell genotypes have been associated with delayed progression to AIDS and shown to be co-inherited in HIV-1-infected individuals who limit viral replication in absence of antiretroviral therapy ('controllers'). However, a comparative analysis of the genotype and function of the innate and adaptive immune compartments in HIV-1-infected controller individuals has been understudied to date.