Open AccessThe impact of HAART on cardiomyopathy among children and adolescents perinatally infected with HIV-1
Author(s) -
Kunjal Patel,
Russell B. Van Dyke,
Murray A. Mittleman,
Steven D. Colan,
James M. Oleske,
George R. Seage
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283578bfa
Subject(s) - human immunodeficiency virus (hiv) , medicine , cardiomyopathy , sida , pediatrics , immunopathology , young adult , viral disease , immunology , heart failure
Previous studies of cardiomyopathy among children perinatally infected with HIV were conducted before the routine use of HAART. Nucleoside analogs [nucleoside reverse transcriptase inhibitors (NRTIs)], the backbone of HAART, have been associated with mitochondrial toxicity, which can lead to cardiomyopathy. We evaluated the association of HAART and specific NRTIs associated with mitochondrial toxicity, on development of cardiomyopathy among perinatally HIV-infected children.