Open AccessImpact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin
Author(s) -
Jessica L. Prodger,
Ronald H. Gray,
Godfrey Kigozi,
Fred Nalugoda,
Ronald M. Galiwango,
Nehemiah Kighoma,
Moses Kakanga,
Taha Hirbod,
Maria J. Wawer,
Nelson Sewankambo,
David Serwadda,
Rupert Kaul
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328354675c
Subject(s) - foreskin , herpes simplex virus , asymptomatic , phenotype , virology , virus , immunology , hsl and hsv , medicine , herpesviridae , biology , viral disease , cell culture , pathology , genetics , gene
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.