Open AccessGlomerular MYH9 expression is reduced by HIV-1
Author(s) -
Thomas Hays,
Vivette D. D’Agati,
Jonathan A. Garellek,
Tjani Warren,
Marc E. Trubin,
Deborah Hyink,
John Cijiang He,
Paul E. Klotman
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328351f6cf
Subject(s) - pathogenesis , podocyte , nephropathy , immunofluorescence , biology , transgene , genetically modified mouse , gene expression , immunology , microbiology and biotechnology , kidney , endocrinology , gene , antibody , proteinuria , genetics , diabetes mellitus
The continuing disease burden of HIV-associated nephropathy (HIVAN) warrants better elucidation of its pathogenic mechanisms. Given that loss of MYH9 function causes a Mendelian renal disease, we hypothesized that renal expression of MYH9 is down-regulated by HIV-1 in HIVAN pathogenesis.