Open AccessRegional differences in predictive accuracy of WHO immunologic failure criteria
Author(s) -
Agnes Kiragga,
Barbara Castelnuovo,
Moses R. Kamya,
Richard Moore,
Yukari C. Manabe
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835143e3
Subject(s) - medicine , predictive value , regimen , human immunodeficiency virus (hiv) , population , antiretroviral treatment , sida , immunology , antiretroviral therapy , viral disease , viral load , environmental health
We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.