Open AccessCellular immune responses and susceptibility to HIV-1 superinfection
Author(s) -
Catherine A. Blish,
OC Dogan,
Walter Jaoko,
R. Scott McClelland,
Kishor Mandaliya,
KS Odem-Davis,
BA Richardsonb,
Julie Overbaugh
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283509a0b
Subject(s) - superinfection , immune system , immunology , cellular immunity , immunopathology , biology , cd8 , cytokine , cytolysis , virology , virus , cytotoxic t cell , in vitro , biochemistry
A case-control study was performed to determine the effects of HIV-1-specific cellular immune responses on the odds of acquiring a second HIV-1 infection (superinfection). Changes in the frequency of cytokine-producing or cytolytic CD8+ or CD4+ T cells were not associated with significant alterations in the odds of superinfection, suggesting that HIV-1 specific cellular immune responses at the level induced by chronic infection do not appear to significantly contribute to protection from HIV-1 superinfection.