Open AccessDifferential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection
Author(s) -
Jin-Hong Chang,
Aurore Lacas,
Robert Lindsay,
Erin Doyle,
Karen L. Axten,
Florencia Pereyra,
Eric Rosenberg,
Bruce D. Walker,
Todd M. Allen,
Marcus Altfeld
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32834f3167
Subject(s) - immunology , tlr2 , plasmacytoid dendritic cell , immune system , innate immune system , tlr7 , toll like receptor , tlr9 , biology , myeloid , dendritic cell , stimulation , peripheral blood mononuclear cell , monocyte , chronic infection , endocrinology , biochemistry , gene expression , dna methylation , gene , in vitro
The objective of this study was to determine changes in toll-like receptor (TLR) responses of monocytes, myeloid dendritic cells and plasmacytoid dendritic cells during primary and chronic HIV-1 infection. TLRs serve as important innate receptors to sense pathogens, and have been implicated in mediating immune activation in HIV-1 infection. Studies assessing the consequences of HIV-1 infection on the ability of innate immune cells to respond to TLR stimulation have come to varying conclusions.