Open AccessA novel role for Slit2/Robo1 axis in modulating HIV-1 replication in T cells
Author(s) -
Appakkudal R. Anand,
Nagaraja Tirumuru,
Ramesh K. Ganju
Publication year - 2011
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32834bab86
Subject(s) - jurkat cells , downregulation and upregulation , viral replication , peripheral blood mononuclear cell , cell culture , biology , virology , microbiology and biotechnology , t cell , chemistry , virus , immunology , in vitro , gene , immune system , genetics
Slit2 is a secreted glycoprotein that has been shown to possess anti-inflammatory properties. In addition, Slit2 has been shown to modulate CXCR4-mediated functional effects in T cells. However, its role in HIV-1 pathogenesis is not known. The objective of the current study is to analyze the role of Slit2 in modulating HIV-1 replication in T cells.