A plasma microRNA signature of acute lentiviral infection | Zendy

Kenneth W. Witwer | Zendy; Stephanie L. Sarbanes | Zendy; Jonathan Liu | Zendy; Janice E. Clements | Zendy

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A plasma microRNA signature of acute lentiviral infection

Author(s) -

Kenneth W. Witwer,

Stephanie L. Sarbanes,

Jonathan Liu,

Janice E. Clements

Publication year - 2011

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32834b95bf

Subject(s) - microrna , virology , signature (topology) , lentivirus , medicine , viral disease , human immunodeficiency virus (hiv) , biology , gene , genetics , geometry , mathematics

Plasma microRNAs (miRNAs) are modulated during disease and are emerging biomarkers; they have not been characterized in HIV infection. Using our macaque/simian immunodeficiency virus (SIV) model of HIV, we sought to identify a plasma miRNA profile of acute lentiviral infection, evaluate its relationship with known cellular and viral determinants of lentivirus-associated central nervous system (CNS) disease, and explore the potential of miRNAs to predict CNS disease.

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