Open AccessMultiple HIV-1-specific IgG3 responses decline during acute HIV-1
Author(s) -
Nicole L. Yates,
Judith T. Lucas,
Tracy L. Nolen,
Nathan Vandergrift,
Kelly A. Soderberg,
Kelly E. Seaton,
Thomas N. Denny,
Barton F. Haynes,
Myron S. Cohen,
Georgia D. Tomaras
Publication year - 2011
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32834b348e
Subject(s) - gp41 , subclass , antibody , antigen , virology , hiv antigens , biology , immunology , immunoglobulin g , human immunodeficiency virus (hiv) , viral disease , epitope
Different HIV-1 antigen specificities appear in sequence after HIV-1 transmission and the immunoglobulin G (IgG) subclass responses to HIV antigens are distinct from each other. The initial predominant IgG subclass response to HIV-1 infection consists of IgG1 and IgG3 antibodies with a noted decline in some IgG3 antibodies during acute HIV-1 infection. Thus, we postulate that multiple antigen-specific IgG3 responses may serve as surrogates for the relative time since HIV-1 acquisition.