Open AccessDelay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide
Author(s) -
Cecilia ChengMayer,
Yaoxing Huang,
Agegnehu Gettie,
Lily L. Tsai,
Wuze Ren,
Madina Shakirzyanova,
Silvana Tasca Sina,
Nataliya Trunova,
James Blanchard,
Lisa M. Jenkins,
Yungtai Lo,
Marco Schito,
Ettore Appella
Publication year - 2011
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32834a1d94
Subject(s) - microbicide , virology , simian immunodeficiency virus , immunology , medicine , vaccination , transmission (telecommunications) , microbicides for sexually transmitted diseases , virus , lentivirus , biology , viral disease , population , human immunodeficiency virus (hiv) , health services , environmental health , electrical engineering , engineering
Development of an effective vaccine or topical compound to prevent HIV transmission remains a major goal for control of the AIDS pandemic. Using a nonhuman primate model of heterosexual HIV-1 transmission, we tested whether a topical microbicide that reduces viral infectivity can potentiate the efficacy of a T-cell-based HIV vaccine.