Open AccessProtective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African–American elite controllers/suppressors
Author(s) -
María Salgado,
Gregory D. Kirk,
Andrea L. Cox,
Alleluiah Rutebemberwa,
Yvonne Higgins,
Jacquie Astemborski,
David L. Thomas,
Chloe L. Thio,
Mark S. Sulkowski,
Joel N. Blankson
Publication year - 2011
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328341b86a
Subject(s) - genotype , snp , single nucleotide polymorphism , hepatitis c virus , virology , immunology , biology , virus , medicine , gene , genetics
We tested the hypothesis that a single nucleotide polymorphism (SNP) located near the interleukin-28B gene is associated with the control of hepatitis C virus and HIV-1 replication in elite controllers/suppressors. We show here that the protective genotype is not overrepresented in elite controllers/suppressors compared with HIV-1-seronegative patients and HIV-1-infected patients with viral loads more than 10 000 copies/ml. Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection.