Open AccessAnti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals
Author(s) -
Mark Manak,
Dmitry Moshkoff,
Lequan T Nguyen,
John Meshki,
Pablo Tebas,
Florin Tuluc,
Steven D. Douglas
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283405c33
Subject(s) - aprepitant , pharmacology , tachykinin receptor 1 , peripheral blood mononuclear cell , substance p , nk1 receptor antagonist , chemistry , medicine , receptor , vomiting , neuropeptide , biochemistry , in vitro , antiemetic
Neurokinin-1 receptor (NK1R) antagonists interfere with binding of neuropeptide substance P to NK1R and exhibit novel anti-HIV-1 activities. Since NK1R antagonists effectively penetrate the blood-brain barrier to reduce the inflammatory response within the brain, we wished to evaluate their potential as anti-HIV-1 candidates for targeting HIV-1 infections of the central nervous system.