Open AccessFine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes
Author(s) -
Michael S. Bennett,
Aviva Joseph,
Hwee Ng,
Harris Goldstein,
Otto O. Yang
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833f7b22
Subject(s) - epitope , avidity , t cell receptor , biology , cytotoxic t cell , virology , t cell , complementarity determining region , major histocompatibility complex , immunology , antigen , genetics , antibody , immune system , monoclonal antibody , in vitro
T-cell receptor (TCR) gene therapy is an approach being considered for HIV-1, but epitope mutation is a significant barrier. We assessed whether HIV-specific TCR can be modified to have broader coverage of epitope variants by recombining polymorphisms between public clonotype TCR sequences.