Open AccessActivation of Notch signaling pathway in HIV-associated nephropathy
Author(s) -
Madhulika Sharma,
Shan Callen,
Da Zhang,
Pravin C. Singhal,
Gregory B. Vanden Heuvel,
Shilpa Buch
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833dbc31
Subject(s) - notch signaling pathway , focal segmental glomerulosclerosis , biology , podocyte , glomerulosclerosis , signal transduction , nephrin , microbiology and biotechnology , western blot , nephropathy , cancer research , notch 1 , glomerulonephritis , endocrinology , kidney , proteinuria , biochemistry , gene , diabetes mellitus
HIV-associated nephropathy (HIVAN) is characterized by the development of glomerulosclerosis and is associated with glomerular epithelial cell proliferation. It has recently been shown that activation of the Notch signaling pathway in podocytes results in glomerulosclerosis and podocyte proliferation. To determine whether Notch signaling is involved in renal disorder associated with HIVAN, we evaluated the expression of Notch receptors in HIVAN.