Open AccessFlexible use of CCR5 in the absence of CXCR4 use explains the immune deficiency in HIV-1 infected children
Author(s) -
Mariangela Cavarelli,
Ingrid Karlsson,
Carla Ripamonti,
A Plebani,
Éva Mária Fenyő,
Gabriella Scarlatti
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833d7d8c
Subject(s) - human immunodeficiency virus (hiv) , immune system , lentivirus , immunology , immunopathology , cxcr4 , medicine , sida , viral disease , virology , chemokine
CCR5-using HIV-1 (R5 viruses) are usually isolated during acute infection from both adults and children. We have recently demonstrated that R5 viruses with a flexible use of CCR5 (called R5broad) can be detected in children close to birth and are predictive of a fast immunological failure. The aim of the present work was to investigate viral phenotype variation during disease progression in HIV-1 infected children, six slow and eight fast progressors.