Open AccessIncreased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
Author(s) -
Janet Lo,
Suhny Abbara,
José A. Rocha-Filho,
Leon Shturman,
Jiann-Wu Wei,
Steven Grinspoon
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833c055a
Subject(s) - adipose tissue , medicine , adiponectin , visceral fat , human immunodeficiency virus (hiv) , endocrinology , obesity , intra abdominal fat , insulin , epicardial fat , lipodystrophy , insulin resistance , antiretroviral therapy , viral load , immunology
Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (rho = 0.76, P < 0.0001), fasting glucose (rho = 0.41, P = 0.001) and insulin (rho = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.