Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection | Zendy

Judith J. Lok | Zendy; Ronald J. Bosch | Zendy; Constance A. Benson | Zendy; Ann C. Collier | Zendy; Gregory K. Robbins | Zendy; Robert W. Shafer | Zendy; Michael D. Hughes | Zendy

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Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection

Author(s) -

Judith J. Lok,

Ronald J. Bosch,

Constance A. Benson,

Ann C. Collier,

Gregory K. Robbins,

Robert W. Shafer,

Michael D. Hughes

Publication year - 2010

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32833adbcf

Subject(s) - antiretroviral therapy , human immunodeficiency virus (hiv) , medicine , term (time) , sida , lentivirus , virology , immunology , immunopathology , viral disease , viral load , intensive care medicine , physics , quantum mechanics

To inform guidelines concerning when to initiate combination antiretroviral therapy (ART), we investigated whether CD4(+) T-cell counts (CD4 cell counts) continue to increase over long periods of time on ART. Losses-to-follow-up and some patients discontinuing ART at higher CD4 cell counts hamper such evaluation, but novel statistical methods can help address these issues. We estimated the long-term CD4 cell count trajectory accounting for losses-to-follow-up and treatment discontinuations.

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