Open AccessLong-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection
Author(s) -
Judith J. Lok,
Ronald J. Bosch,
Constance A. Benson,
Ann C. Collier,
Gregory K. Robbins,
Robert W. Shafer,
Michael D. Hughes
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833adbcf
Subject(s) - antiretroviral therapy , human immunodeficiency virus (hiv) , medicine , term (time) , sida , lentivirus , virology , immunology , immunopathology , viral disease , viral load , intensive care medicine , physics , quantum mechanics
To inform guidelines concerning when to initiate combination antiretroviral therapy (ART), we investigated whether CD4(+) T-cell counts (CD4 cell counts) continue to increase over long periods of time on ART. Losses-to-follow-up and some patients discontinuing ART at higher CD4 cell counts hamper such evaluation, but novel statistical methods can help address these issues. We estimated the long-term CD4 cell count trajectory accounting for losses-to-follow-up and treatment discontinuations.