Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure | Zendy

Weerawat Manosuthi | Zendy; David M. Butler | Zendy; Josué PérezSantiago | Zendy; Art F. Y. Poon | Zendy; Satish K. Pillai | Zendy; Sanjay R. Mehta | Zendy; Mary E. Pacold | Zendy; Douglas D. Richman | Zendy; Sergei L. Kosakovsky Pond | Zendy; Davey M. Smith | Zendy

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Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure

Author(s) -

Weerawat Manosuthi,

David M. Butler,

Josué PérezSantiago,

Art F. Y. Poon,

Satish K. Pillai,

Sanjay R. Mehta,

Mary E. Pacold,

Douglas D. Richman,

Sergei L. Kosakovsky Pond,

Davey M. Smith

Publication year - 2010

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e3283350eef

Subject(s) - virology , human immunodeficiency virus (hiv) , lentivirus , immune system , antiretroviral therapy , immunopathology , immunology , medicine , host (biology) , biology , viral disease , viral load , genetics

Most of our knowledge about how antiretrovirals and host immune responses influence the HIV-1 protease gene is derived from studies of subtype B virus. We investigated the effect of protease resistance-associated mutations (PRAMs) and population-based HLA haplotype frequencies on polymorphisms found in CRF01_AE pro.

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