Open AccessProtease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure
Author(s) -
Weerawat Manosuthi,
David M. Butler,
Josué Pérez-Santiago,
Art F. Y. Poon,
Satish K. Pillai,
Sanjay R. Mehta,
Mary E. Pacold,
Douglas D. Richman,
Sergei L. Kosakovsky Pond,
Davey M. Smith
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283350eef
Subject(s) - virology , human immunodeficiency virus (hiv) , lentivirus , immune system , antiretroviral therapy , immunopathology , immunology , medicine , host (biology) , biology , viral disease , viral load , genetics
Most of our knowledge about how antiretrovirals and host immune responses influence the HIV-1 protease gene is derived from studies of subtype B virus. We investigated the effect of protease resistance-associated mutations (PRAMs) and population-based HLA haplotype frequencies on polymorphisms found in CRF01_AE pro.