Open AccessA polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro
Author(s) -
Woohyun Yoon,
Benjiang Ma,
Jacques Fellay,
Wei Huang,
Shi-Mao Xia,
Ruijun Zhang,
Kevin V. Shianna,
HuaXin Liao,
Barton F. Haynes,
David B. Goldstein
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833202f5
Subject(s) - biology , haplotype , gene , infectivity , human leukocyte antigen , allele , genetics , in vitro , virology , virus , antigen
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.