Open AccessMonocyte CD49e and 110–120 kDa fibronectin fragments: HIV prognostic indicators independent of viral load and CD4 T-cell counts
Author(s) -
Roger D. Rossen,
José Rubio,
Wendy J. Porter,
JoAnn Trial,
Frank M. Orson,
Maria C. RodriguezBarradas,
Holly H. Birdsall
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283318ff4
Subject(s) - monocyte , flow cytometry , inflammation , immunology , viral load , medicine , chemistry , human immunodeficiency virus (hiv)
To investigate the prognostic impact of chronic inflammation associated with HIV infections. Previously, we had observed that proteases, released in the course of HIV infections, cause 110-120 kDa fibronectin fragments (FNf) to appear in the blood of many patients. In vitro, at concentrations within the range found in patients' plasma, FNf stimulate monocytes to release proteolytic enzymes that remove CD49e from the cell surface and produce cytokines that suppress proliferation of activated T cells when stimulated by agents that crosslink their antigen receptors.