Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring | Zendy

Olivia Keiser | Zendy; Hannock Tweya | Zendy; Andrew Boulle | Zendy; Paula Braitstein | Zendy; Mauro Schecter | Zendy; Martin W. G. Brinkhof | Zendy; François Dabis | Zendy; Suely Tuboi | Zendy; Eduardo Sprinz | Zendy; Mar PujadesRodríguez | Zendy; Alexandra Calmy | Zendy; Nagalingeswaran Kumarasamy | Zendy; Denis Nash | Zendy; Andreas Jahn | Zendy; Patrick MacPhail | Zendy; R Lüthy | Zendy; Robin Wood | Zendy; Matthias Egger | Zendy

Open Access

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring

Author(s) -

Olivia Keiser,

Hannock Tweya,

Andrew Boulle,

Paula Braitstein,

Mauro Schecter,

Martin W. G. Brinkhof,

François Dabis,

Suely Tuboi,

Eduardo Sprinz,

Mar PujadesRodríguez,

Alexandra Calmy,

Nagalingeswaran Kumarasamy,

Denis Nash,

Andreas Jahn,

Patrick MacPhail,

R Lüthy,

Robin Wood,

Matthias Egger

Publication year - 2009

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32832e05b2

Subject(s) - viral load , interquartile range , medicine , hazard ratio , immunology , confidence interval , virology , human immunodeficiency virus (hiv)

In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line regimens to protease inhibitor-based regimens in Africa, South America and Asia.

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