Open AccessHost genetics and HIV-1 viral load set-point in African–Americans
Author(s) -
Sadeep Shrestha,
Brahim Aı̈ssani,
Wei Song,
Craig M. Wilson,
Richard A. Kaslow,
Jianming Tang
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328325d414
Subject(s) - viral load , biology , human leukocyte antigen , linkage disequilibrium , single nucleotide polymorphism , genetics , genotype , allele , major histocompatibility complex , immunology , mhc class i , locus (genetics) , virology , virus , immune system , antigen , gene
In a recent genome-wide association study of HIV-1-infected individuals in the Euro-CHAVI cohort, viral load set-point was strongly associated with genotypes defined by two single nucleotide polymorphisms (SNPs) (rs9264942 and rs2395029) within the human major histocompatibility complex (MHC) region on chromosome 6. We attempted to confirm this finding in African-Americans and to address whether these SNPs are in linkage disequilibrium with human leukocyte antigen (HLA) class I alleles that mediate innate and adaptive immunity.