Open AccessInterruption of antiretroviral therapy is associated with increased plasma cystatin C
Author(s) -
Amanda Mocroft,
Christina M. Wyatt,
Lynda A. Szczech,
Jacquie Neuhaus,
Wafaa ElSadr,
Russell P. Tracy,
Lewis H. Kuller,
Michael G. Shlipak,
Brian Angus,
H. Klinker,
Michael J. Ross
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32831cc129
Subject(s) - cystatin c , randomization , odds ratio , medicine , confidence interval , gastroenterology , randomized controlled trial , cystatin , immunology , renal function
Cystatin C has been proposed as an alternative marker of renal function. We sought to determine whether participants randomized to episodic use of antiretroviral therapy guided by CD4 cell count (drug conservation) had altered cystatin C levels compared with those randomized to continuous antiretroviral therapy (viral suppression) in the Strategies for Management of Antiretroviral Therapy trial, and to identify factors associated with increased cystatin C.