Open AccessMitochondrial DNA haplogroups influence AIDS progression
Author(s) -
Sher L. Hendrickson,
Holli Hutcheson,
Eduardo RuizPesini,
Jason C. Poole,
James A. Lautenberger,
Efe Sezgın,
Lawrence A. Kingsley,
James J. Goedert,
David Vlahov,
Sharyne Donfield,
Douglas C. Wallace,
Stephen J. O’Brien
Publication year - 2008
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32831940bb
Subject(s) - haplogroup , mitochondrial dna , human mitochondrial dna haplogroup , haplotype , disease , cohort , biology , cohort study , mitochondrion , medicine , single nucleotide polymorphism , multicenter aids cohort study , immunology , genotype , gene , genetics , viral disease , sida , human immunodeficiency virus (hiv)
Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA single-nucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis.