Open AccessA common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers
Author(s) -
Rae-Anne Hardie,
E. H. Knight,
Brigitte Bruneau,
Christina A. D. Semeniuk,
Kulvinder K. Gill,
Nico Nagelkerke,
Joshua Kimani,
Charles Wachihi,
Elizabeth Ngugi,
Ma Luo,
Francis A. Plummer
Publication year - 2008
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328311d1a0
Subject(s) - immunology , seroconversion , genotype , antigen , odds ratio , confidence interval , virology , medicine , biology , human immunodeficiency virus (hiv) , gene , genetics
Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.