Open AccessUse of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients
Author(s) -
Dad Study Groups
Publication year - 2008
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32830fe35e
Subject(s) - reverse transcriptase , nucleoside reverse transcriptase inhibitor , myocardial infarction , didanosine , human immunodeficiency virus (hiv) , medicine , reverse transcriptase inhibitor , virology , nucleoside , viral disease , sida , antiretroviral therapy , viral load , biology , polymerase chain reaction , biochemistry , gene
Two nucleos(t)ide reverse transcriptase inhibitors (NRTIs)--abacavir and didanosine--may each be associated with excess risk of myocardial infarction. The reproducibility of this finding in an independent dataset was explored and plausible biological mechanisms were sought.