Open AccessCD4 deficits and disease course acceleration can be driven by a collapse of the CD8 response in rhesus macaques infected with simian immunodeficiency virus
Author(s) -
Maria Cecília Garibaldi Marcondes,
Sieghart Sopper,
Ulrike Sauermann,
Tricia H. Burdo,
Debbie D. Watry,
Michelle Zandonatti,
Howard S. Fox
Publication year - 2008
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283052fb5
Subject(s) - simian immunodeficiency virus , virology , human immunodeficiency virus (hiv) , disease , immunology , immunodeficiency , cd8 , medicine , immune system
Defects in memory CD4+ T cells correlate with development of AIDS in monkeys infected with simian immunodeficiency virus, but the early events leading to these deficits are unknown. We explored the role of cells specific to simian immunodeficiency virus and CD8 cells in the determination of CD4 failure and rapid disease course.