Open AccessAfrican infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine
Author(s) -
Louise Kuhn,
Diana B. Schramm,
Samantha L. Donninger,
Stephen MeddowsTaylor,
Ashraf Coovadia,
Gayle Sherman,
Glenda Gray,
Caroline T. Tiemessen
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3282ba553a
Subject(s) - nevirapine , virology , ccl3 , lentivirus , medicine , human immunodeficiency virus (hiv) , gene , biology , immunology , genetics , viral disease , viral load , antiretroviral therapy , chemokine , immune system , ccl2
Individuals with more copies of CCL3L1 (CCR5 ligand) than their population median have been found to be less susceptible to HIV infection. We investigated whether maternal or infant CCL3L1 gene copy numbers are associated with perinatal HIV transmission when single-dose nevirapine is given for prevention.