Open AccessA compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis
Author(s) -
Stephanie M. Dillon,
Kejun Guo,
Gregory L. Austin,
Sara Gianella,
Phillip A. Engen,
Ece Mutlu,
John Losurdo,
Garth Swanson,
Prachi Chakradeo,
Ali Keshavarzian,
Alan Landay,
Mario L. Santiago,
Cara C. Wilson
Publication year - 2018
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000001863
Subject(s) - immunology , interferon , biology , immune system , peripheral blood mononuclear cell , virology , in vitro , biochemistry
Type I interferon (IFN-I) responses confer both protective and pathogenic effects in persistent virus infections. IFN-I diversity, stage of infection and tissue compartment may account for this dichotomy. The gut is a major site of early HIV-1 replication and microbial translocation, but the nature of the IFN-I response in this compartment remains unclear.