Open AccessInteracting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis
Author(s) -
Yisel M. Cantres-Rosario,
Natalia Carballo Hernández,
Karla Negrón,
Juliana Pérez-Laspiur,
John D. Leszyk,
Scott A. Shaffer,
Loyda M. Meléndez
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000823
Subject(s) - apoptosis , macrophage , cathepsin , cathepsin s , cathepsin b , human immunodeficiency virus (hiv) , biology , microbiology and biotechnology , virology , immunology , genetics , enzyme , in vitro , biochemistry
HIV-1 infection of macrophages increases cathepsin B secretion and induces neuronal apoptosis, but the molecular mechanism remains unclear.