Open AccessLack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation
Author(s) -
Christopher W. Peterson,
Kevin G. Haworth,
Patricia Polacino,
Meei Li Huang,
Craig Sykes,
Willimark Obenza,
Andrea C. Repetto,
Angela D. M. Kashuba,
Roger E. Bumgarner,
Stephen C. DeRosa,
Ann E. Woolfrey,
Keith R. Jerome,
James I. Mullins,
Shiu Lok Hu,
Hans Peter Kiem
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000702
Subject(s) - viremia , cart , viral load , immunology , simian immunodeficiency virus , hematopoietic stem cell transplantation , medicine , transplantation , virus , virology , biology , mechanical engineering , engineering
We have previously demonstrated robust control of simian/human immunodeficiency virus (SHIV1157-ipd3N4) viremia following administration of combination antiretroviral therapy (cART) in pigtailed macaques. Here, we sought to determine the safety of hematopoietic stem cell transplantation (HSCT) in cART-suppressed and unsuppressed animals.