Open AccessCell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4
Author(s) -
Guan Han Li,
C E Anderson,
Laura Jaeger,
Thao Do,
Eugene O. Major,
Avindra Nath
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000605
Subject(s) - biology , cell , microbiology and biotechnology , cell type , confocal microscopy , cell fusion , astrocyte , virology , immunology , central nervous system , neuroscience , genetics
HIV reservoir in the brain represents a major barrier for curing HIV infection. As the most abundant, long-lived cell type, astrocytes play a critical role in maintaining the reservoir; however, the mechanism of infection remains unknown. Here, we determine how viral transmission occurs from HIV-infected lymphocytes to astrocytes by cell-to-cell contact.