Open AccessHIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy
Author(s) -
Sophie Borel,
Véronique Robert-Hebmann,
Jamal Alfaisal,
Ashish Jain,
Mathias Faure,
Lucile Espert,
Laurent Chaloin,
Jean-Christophe Paillart,
Terje Johansen,
Martine Biard-Piechaczyk
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000554
Subject(s) - autophagy , atg8 , apobec3g , microbiology and biotechnology , biology , cytidine deaminase , infectivity , virology , viral replication , virus , antibody , apoptosis , biochemistry , genetics
Autophagy, an important antiviral process triggered during HIV-1 entry by gp41-dependent membrane fusion, is repressed in infected CD4+ T cells by an unknown mechanism. The aim of this study was to identify the role of viral infectivity factor (Vif) in the autophagy blockade.