Open AccessDifferent expression of Blimp-1 in HIV infection may be used to monitor disease progression and provide a clue to reduce immune activation and viral reservoirs
Author(s) -
Francesco Nicoli,
Fabio Sforza,
Riccardo Gavioli
Publication year - 2015
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000514
Subject(s) - viral load , immunology , immune system , biology , disease , t cell , virology , human immunodeficiency virus (hiv) , medicine , pathology
Blimp-1 expression may be a marker to monitor the course of HIV infection as well as response to therapy. It is tempting to speculate that Blimp-1 expression may be modulated by immunotherapeutic strategies, although this approach needs strong caution due to its dual effect according to the disease phase. Indeed, as already proposed, Blimp-1 expression may be reduced during active progression to decrease immune activation, viral spread and reservoir establishment. On the contrary, Blimp-1 induction in chronically HIV-infected HAART- treated individuals may favor reservoir purging