Open AccessSequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03
Author(s) -
Nienke H. van Teijlingen,
Angelique Hölzemer,
Christian Körner,
Wilfredo F. García-Beltrán,
Jamie L. Schafer,
Lena Fadda,
Todd J. Suscovich,
Christian Berthou,
Mary Carrington,
David T. Evans,
Debbie van Baarle,
Marcus Altfeld
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000284
Subject(s) - epitope , human leukocyte antigen , human immunodeficiency virus (hiv) , virology , sequence (biology) , group specific antigen , biology , lentivirus , immunology , computational biology , genetics , viral disease , antigen
The aim of this study was to assess the consequence of sequence variations in HLA-C03:04-presented HIV-1 p24 Gag epitopes on binding of the inhibitory natural killer (NK) cell receptor KIR2DL2 to HLA-C03:04.