Open AccessInterleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence
Author(s) -
Sara Tanaskovic,
Sonia Fernández,
Patricia Price,
Martyn A. French
Publication year - 2014
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000000213
Subject(s) - interleukin 7 receptor , t cell , naive t cell , immunology , biology , immune system , cd8 , cytotoxic t cell , microbiology and biotechnology , t cell receptor , il 2 receptor , in vitro , biochemistry
To examine the relationship of defects in interleukin (IL)-7-induced naive CD4 T-cell homeostasis with residual immune activation and CD4 T-cell senescence in HIV patients receiving antiretroviral therapy (ART) who exhibit persistent CD4 T-cell deficiency.